Sub-total Parathyroidectomy Reduces Vascular Calcification in Haemodialysis Patients
试验速览
- 阶段
- 不适用
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Change in vascular calcium scores
研究概览
简要总结
The aim of this study was to evaluate whether successful sub-total parathyroidectomy retards cardiovascular calcification in patients with hemodialysis and to investigate the mechanism .
详细描述
Hyperparathyroidism (PHPT) in patients with end-stage renal disease have been shown to have an increased morbidity and mortality mainly due to cardiovascular disease. The precise mechanism of cardiovascular disease in PHPT is not well understood . The excess in cardiovascular mortality is significantly and independently related to serum calcium, the connection between the biochemical disturbances and the cardiovascular disorders in PHPT patients is not necessarily a cause-and-effect relationship. Indeed, the impact of surgical cure of hyperparathyroidism on cardiovascular risk factors and mortality is controversial. Some studies suggest that cardiovascular risk markers remained unaltered after Sub-total Parathyroidectomy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •The patients receiving hemodialysis treatment, with elevated intact parathyroid hormone (iPTH) levels > 800pg/ml on two or more occasions.
- •Patients with parathyroid nodular or diffuse hyperplasia identified by ultrasound imaging or radioisotope scan.
排除标准
- •Patients with significant background valvular heart disease
- •Patients who are unfit for general anaesthesia
- •Patients with acute myocardial infarction within recent two months
- •Patients with poor general condition
- •Patients with plans for living related kidney transplant within 1 year
- •Patients with previous history of parathyroidectomy
研究组 & 干预措施
Sub-total Parathyroidectomy
干预措施: Sub-total Parathyroidectomy (Procedure)
结局指标
主要结局
Change in vascular calcium scores
时间窗: 12 months
次要结局
- Change in left ventricular systolic and diastolic function(12 months)