NCT03937349已完成不适用
Impact of Parathyroidectomy on Cardiovascular Calcification in Dialysis-dependent Patients: a Prospective Cohort Study
Saint Petersburg State University, Russia1 个研究点 分布在 1 个国家目标入组 63 人开始时间: 2019年5月14日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 63
- 试验地点
- 1
- 主要终点
- Change in coronary artery calcium score measured with CT
研究概览
简要总结
This is a prospective cohort study aimed to evaluate change of cardiovascular calcification after parathyroidectomy in patients with end-stage renal disease on dialysis compared with control group on conservative treatment.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age > 18 years
- •ESRD patients receiving long-term hemodialysis or peritoneal dialysis treatment
- •Severe secondary hyperparathyroidism defined as iPTH level > 800 pg/ml, followed with hypercalcemia and/or hyperphosphatemia; with presence of one or more nodular or diffuse parathyroid hyperplasia confirmed with CT
排除标准
- •Primary hyperparathyroidosis as a cause of ESRD
结局指标
主要结局
Change in coronary artery calcium score measured with CT
时间窗: 18 months
Change in vascular calcification score measured with semi-quantitative (Kauppila) test
时间窗: 18 months
次要结局
- Change in serum phosphate level(18weeks)
- Change in alkaline phosphatase(18 months)
- Change in intact parathyroid hormone (iPTH) level(18 months)
- Change in serum calcium level(18 months)
- Change in heart valve calcium score(18 months)
- Serious adverse events (cardiovascular events, death, fractures, emergency hospital admissions) during the follow-up period(18 months)
研究者
Ekaterina Parshina
Principal investigator
Saint Petersburg State University, Russia
研究点 (1)
Loading locations...
相似试验
已完成
不适用
Impact of Parathyroidectomy on Vascular Calcification and Clinical Outcome in Hemodialysis PatientsHyperparathyroidism, SecondaryNCT03724188Mansoura General Hospital55
Unknown
不适用
Sub-total Parathyroidectomy Reduces Vascular Calcification in Haemodialysis PatientsHemodialysisNCT01140490Guangdong Provincial People's Hospital40
已完成
不适用
Effects of Parathyroidectomy on Cardiovascular Risk Factors in Primary HyperparathyroidismPrimary HyperparathyroidismNCT01057732HaEmek Medical Center, Israel76
已完成
不适用
Parathyroidectomy in Endstage Renal DiseaseEndstage Renal DiseaseNCT00745719The University of Hong Kong122
已完成
不适用
Effect of Parathyroidectomy on SleepHyperparathyroidismNCT00501215M.D. Anderson Cancer Center15