Effect of Duloxetine in knee osteoarthritis

Phase 3

• Conditions: Osteoarthritis of knee.; Osteoarthritis of knee

• Registration Number: IRCT20230821059204N1
• Lead Sponsor: Mazandaran University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 16 October 2023

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Patients aged 40-80 years
Knee pain more than 14 days per month and the average pain score Visual Analogue score (VAS) = 4 during the 3-month period before the first visit
The grade of knee osteoarthritis is 2 and 3 based on the Kallgren-Lawrence classification
BMI =40
The knee should be stable
Good cognitive status
The ability to understand the study protocol and the mental ability to answer the questions of the questionnaires
Willingness to participate in the study

Exclusion Criteria

Deformity of the knee
Spondylolisthesis
Lumbar radiculopathy
Inflammatory arthritis
Autoimmune disorder
Septic arthritis
Any other concomitant disease such as liver and kidney disease
Contraindications for duloxetine (current use of monoamine oxidase inhibitors or poorly controlled angle-closure glaucoma)
Previous exposure to duloxetine
Concomitant use of other drugs that affect the central nervous system (such as benzodiazepines)
History of allergy to duloxetine
Metabolic diseases
Anticoagulation therapy
pregnancy
History of aggressive knee treatments in the last 6 months
Knee joint replacement at any time
Current infection in the affected limb

Study & Design

• Study Type: interventional
• Study Design: Not specified