Comparison of the effectiveness of duloxetine and nortriptyline in the treatment of pain in rheumatoid arthritis patients
- Conditions
- pain.
- Registration Number
- IRCT20220901055848N1
- Lead Sponsor
- Shahid Beheshti University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 54
Confirmation of the clinical diagnosis of mild to moderate Rheumatoid Arthritis by a rheumatologist
Presence of RF or AntiCCP in the serum of patients
Patients under treatment with methotrexate, prednisolone and hydroxychloroquine
Articular involvement without extra-articular involvement
Age range from 18 to 70 years
Pain complaint
Consent to participate in the study
The presence of major psychiatric disorders, including depression, anxiety disorders, bipolar, schizophrenia, abuse of any substance and medication.
History of allergy to Duloxetine or Nortriptyline
Pregnancy, breastfeeding, or planning to become pregnant in the near future
Refusing to consent to receive treatment according to the instructions of this protocol
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pain level. Timepoint: Pain measurement before, 1 month, 2 months and 3 months after the start of taking one of the two drugs Nortriptyline and Duloxetine. Method of measurement: Visual Analogue Scale.
- Secondary Outcome Measures
Name Time Method