Evaluating the efficacy of duloxetine and gabapentin in pain reduction in patients with knee osteoarthritis
Phase 3
Recruiting
- Conditions
- Knee osthoarthritis.Osteoarthritis, unspecified site
- Registration Number
- IRCT20170716035126N2
- Lead Sponsor
- Ardabil University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 150
Inclusion Criteria
idiopathic knee osteoarthritis
Age between 45-75 years
ability to walk
having pain score of >5 according to VAS and >48 according to WOMAC questionnaire
Exclusion Criteria
Other knee disorders
Concomitant hip and ankle osteoarthritis
Bursitis and perarticular disease
radicular pains
physiotherapy or intraarticular injection during the past 6 months
psychological disease
history of knee surgery
inflammatory joint disease
rheumatoid arthritis
fibromyalgia
active or recurrent pseudogoat
malignancy;
systemic diseases including renal of hepatic failure, uncontrolled blood pressure, diabetes mellitus
asthma in need of corticosteroids
corticosteroid use in less than 5 weeks prior to study
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pain. Timepoint: Before intervention and one and three months after intervention. Method of measurement: Using visual analogue scale (VAS).
- Secondary Outcome Measures
Name Time Method Functional status. Timepoint: Before intervention and one and three months after intervention. Method of measurement: using Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaire.;Quality of life. Timepoint: Before intervention and one and three months after intervention. Method of measurement: Using SF-12 quality of life questionnaire.