oninvasive Imaging of Vulnerable Inflammatory Coronary Plaque using Cardiac PET/CT in Humans: a feasibility study

Phase 2

Completed

• Conditions: 10011082; Coronary artery disease; unstable angina

• Registration Number: NL-OMON44976
• Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 24

Inclusion Criteria

* Patients with an acute coronary syndrome and accompanying ECG abnormalities (unstable angina / non-ST-elevation myocardial infarction.
* Clinical indication for invasive coronary angiography within 72 hours upon admission based on ESC guidelines pertaining treatment of patients with unstable angina or non-ST segment elevation myocardial infarction.
* Age 35-75 years

Exclusion Criteria

* Prior percutaneous coronary intervention, coronary artery bypass surgery, or myocardial infarction
* History of systemic inflammatory disease
* Current cardiac arrhythmia
* Renal failure with estimated glomerular filtration rate < 45 ml/min
* Refusal or inability to give informed consent

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>This feasibility study will test different tracers for their feasibility to<br /><br>detect culprit lesions of patients with an ACS. Endpoints will be sufficient<br /><br>target to background uptake of tracer beyond 1.2 that coincides with the<br /><br>culprit lesion identified with general clinical information / CAG / OCT<br /><br>characteristics.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Kinetics of the three different PET tracers (11C-PK11195, 18F-AS101, or<br /><br>18F-Galacto-RGD)</p><br>