Effect of Remote Ischemic Preconditioning on Lung Injury in Patients Undergoing Pulmonary Resection:a Randomised Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 108
- 试验地点
- 1
- 主要终点
- Limb remote ischemic preconditioning has effective protection of lung injury in patients undergoing pulmonary lobectomy
研究概览
简要总结
The purpose of this study is to determine whether ischemic preconditioning reduces lung injury in patients undergoing pulmonary resection.
详细描述
Remote ischemic preconditioning is an intervention in which brief ischemia of one tissue or organ protects remote organs from a sustained episode of ischemia. It is known that one-lung ventilation in patients undergoing pulmonary resection, which may cause acute lung injury. The investigators did a single-blinded randomised controlled study to establish whether remote ischemic preconditioning reduces lung injury in these patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinical diagnosis of pulmonary carcinoma
- •Must be received pulmonary lobectomy
排除标准
- •Cardiac disease categorized as NYHA classes II-IV
- •Preoperative severe impairment of respiratory function (arterial oxygen tension (PaO2) <60 mmHg or FEV1<50% predicted),
- •Pre-existing coagulopathy or thrombocytopenia
- •Prior receipt of chemotherapy or radiation therapy or immunotherapy
- •Systemic or local active infections (either clinically defined or suggested by evidence such as elevated C-reactive protein levels, leukocytosis, or a body temperature>38℃)
- •Peripheral vascular disease affecting the upper limbs
- •Administration of vitamins, nonsteroidal anti-inflammatory agent or corticosteroid within 3 months.
结局指标
主要结局
Limb remote ischemic preconditioning has effective protection of lung injury in patients undergoing pulmonary lobectomy
时间窗: June,2013
PaO2/FiO2 in the limb RIPC group was significantly higher than that in the control group at 30 and 60 min after OLV, 30 min and 6 h after operation (all P\<0.05)
次要结局
- Cs and Cd(June,2013)
- IL-6 and TNF-α(June,2013)
研究者
Cai Li
Department of Anesthesiology, First Affiliated Hospital, Sun Yat-Sen University
First Affiliated Hospital, Sun Yat-Sen University