The effect of topical ketorolac on knee osteoarthritis

Phase 2

Conditions: Knee osteoarthritis.
Osteoarthritis of knee

Registration Number: IRCT20190810044500N22

Lead Sponsor: Yazd University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: All

Target Recruitment: 40

Inclusion Criteria

Age over 40
Primary osteoarthritis
Pain in more than half of the days of the previous month during one of the following activities: walking, going up and down stairs, standing or lying on a bed or mattress during Night
Radiographic evidence of tibiofemoral or patellofemoral osteoarthritis
baseline score of 40 on the WOMAC scale
no intra-articular injection of hyaluronic acid / glucocorticoid during the last six months
no positive pregnancy test or pregnancy program during the study

Exclusion Criteria

Not taking the right medicine
Serious medical condition in which the patient is unable to return for regular visits
History of liver disease
Inability to walk without a cane
Secondary osteoarthritis for example following trauma

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Joint range of motion. Timepoint: At the beginning of the study and 7 and 14 days after starting topical ketorolac and topical diclofenac. Method of measurement: Western ontario and mc master universities osteoarthritis index and Knee Injury and Osteoarthritis Outcome Score.

Secondary Outcome Measures

Name	Time	Method
Pain. Timepoint: At the beginning of the study and 7 and 14 days after starting ketorolac topical and diclofenac. Method of measurement: Western Ontario and mc master universities osteoarthritis index and Visual Analogue Scale and Knee Injury and Osteoarthritis Outcome Score.;Inflammation. Timepoint: At the beginning of the study and 7 and 14 days after starting ketorolac topical and diclofenac. Method of measurement: Western ontario and mc master universities osteoarthritis index and Visual Analogue Scale and Knee Injury and Osteoarthritis Outcome Score.