PACTR202106791732070招募中1 期
Pharmacokinetics and pharmacogenomics of Tamoxifen in healthy volunteers: The effects of African specific CYP2D6*17 genotype on the plasma levels of Tamoxifen and its metabolites
AiBST0 个研究点目标入组 42 人开始时间: 2020年5月7日最近更新:
适应症
试验速览
- 阶段
- 1 期
- 状态
- 招募中
- 发起方
- 入组人数
- 42
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 19 Year(s) 至 44 Year(s)（—）
- 性别
- All
入选标准
- •Male and female subjects aged 18 to 30 years (inclusive).
- •Good health as determined by past medical history, physical examination, vital signs, ECG, and laboratory tests at screening.
- •Be able to communicate and understand the consent process
- •Be of the following CYP2D6 genotypes: CYP2D6*1/*1, CYP2D6*1/*2, CYP2D6*2/*2, CYP2D6*1/*17 and CYP2D6*17/*17
- •BMI between 19 to 27 kg/m2 (inclusive)
排除标准
- •1. Pregnant women
- •2. On medication that is known to inhibit CYP2D6 such as antidepressants and antipsychotics
- •3. Any other CYP2D6 genotypes which are not CYP2D6*1/*1, CYP2D6*1/*2, CYP2D6*2/*2, CYP2D6*1/*17 and CYP2D6*17/*17
- •4. Breastfeeding women
- •5. Smokers who report a daily use more than 10 cigarettes
- •6. Use of prescription drugs or OTC medication
- •7. Participation in any clinical in
研究者
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