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Tamoxifen population pharmacokinetics in breast cancer patients: metabolism study, genetic polymorphism, hormonal status and age
Faculdade de Ciências Farmacêuticas de Ribeirão Preto0 个研究点开始时间: 2018年7月23日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18Y 至 90Y（—）
- 性别
- Female
入选标准
- •Breast cancer patients on adjuvant tamoxifen treatment for more than 80 days who have not been treated with other co-medications that may interfere with the study have been investigated. For the study, two groups of patients will be delimited according to age and hormonal status, being a premenopausal group (age less than 50 years) and another postmenopause (age higher than 60 years).
排除标准
- •Patients with comorbidities that interfere with the metabolism of tamoxifen and the probe drugs were excluded; patients who have previously chemotherapy and / or target therapy; patients who have contraindications to the use of the probe drugs metoprolol, midazolam and fexofenadine; and psychiatric patients unable to understand ICF.
研究者
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