Metabolomic Profiling of Urine Samples for the Identification of Novel Biomarkers and Mechanisms in the Diagnosis and Management of Malodor Associated With Metabolic Inefficiencies
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Nutritional and Metabolic Diseases
- Sponsor
- Mebo Research, Inc.
- Enrollment
- 39
- Locations
- 2
- Primary Endpoint
- Differences in Metabolite Concentrations in Urine Between Individuals With Malodor Issues and Age-matched Healthy Controls.
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
The purpose of this study is to identify metabolic signatures associated with malodor conditions. The investigators will perform state-of-the art metabolomics tests and bioinformatic data mining to explore if conditions leading to malodor can be screened by metabolomic profiling of urine samples.
Detailed Description
In this study, metabolite profiling analysis will be carried out on urine samples of individuals with malodor conditions related to metabolism inefficiencies. Metabolic profiles will be identified using the metabolomics equipment located in the NMR, HPLC and MS facilities of the Metabolomics Innovation Centre (TMIC). Multivariate statistical analyses will be used, as well as other approaches to mine complex data from heterogeneous sources.
Investigators
Eligibility Criteria
Inclusion Criteria
- •18 years or older
- •unpredictable and uncontrollable episodes of malodor
- •willing and able to ship a urine sample (in the kit provided) by an overnight courier to Edmonton, Alberta, Canada
- •good general health
Exclusion Criteria
- •serious medical conditions that require treatment
- •conditions that, in the opinion of the investigator, would prevent participation
- •under the age of 18
- •elect not to participate in the study
Outcomes
Primary Outcomes
Differences in Metabolite Concentrations in Urine Between Individuals With Malodor Issues and Age-matched Healthy Controls.
Time Frame: time from diagnostic urine sample collection to dispatch of results
The investigators would like to validate if urine metabolomic profiling can be used for identifying key metabolomic signatures associated with malodor. Differences in metabolite concentrations will be measured by mass spectrometry, to compare urine samples from individuals with malodor issues, and age-matched healthy controls.
Secondary Outcomes
- Correlations Between Urine Biomarkers and Frequency/Severity of Malodor Symptoms (Questionnaires)(time from sample collection to notification of results and follow-up needed.)