Discovery of Novel Biomarkers of Dietary Exposure in the EPIC Calibration Study

Completed

• Conditions: Dietary Exposure

• Registration Number: NCT03683654
• Lead Sponsor: International Agency for Research on Cancer

Brief Summary

This proposal aims at identifying new biomarkers of dietary exposure using metabolomic approaches. This project is based on the European Prospective Investigation on Cancer and Nutrition (EPIC) Calibration Study and more particularly upon a subset of 494 men and women from 4 European countries (Germany, Greece, Italy and France). Urine and blood samples are analyzed by untargeted metabolomics.

Detailed Description

Subjects participating in the study are characterized by the availability of one 24-hr urine sample, blood serum, 24-hr dietary recall (24HDR) and food frequency questionnaire (FFQ) data.

The main objectives of the proposal are:

1. To collect a set of high-quality metabolomic data containing rich information on the food-derived metabolome.

2. To mine this data in different Metabolome-Wide Association Studies in order to identify food-derived metabolites discriminating consumers and non-consumers of various foods, nutrients and dietary patterns.

3. To identify the food-derived metabolites characteristic of the consumption of the different foods/nutrients and dietary patterns.

Study Timeline

• Study Start: 2012-04-26
• Primary Completion: 2013-02-23
• Study Completion: 2013-02-23
• Study First Submitted: 2018-09-21
• Study First Submitted QC: 2018-09-24
• Study First Posted: 2018-09-25
• Status Verified: 2018-10
• Last Update Submitted: 2018-10-08
• Last Update Posted: 2018-10-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 494

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Metabolite concentrations in plasma and urine	1 day	Food-derived Metabolite concentrations in plasma and urine are measured by high resolution mass spectrometry coupled to ultrahigh performance chromatography.