Effect of Aromatic and Warming-up Therapy in Coronary Microvascular Disease: a Multicenter, Randomized, Double-blind, Placebo-controlled Clinical Study.
- Conditions
- Coronary Microvascular Disease
- Registration Number
- ITMCTR2200005704
- Lead Sponsor
- Xiyuan Hospital, Chinese Academy of Traditional Chinese medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- Not specified
(1) Meet the CMVD diagnostic criteria;
(2) All TCM interventions will be stopped for more than 2 weeks or more;
(3) Between 20 and 75, men and women;
(4) The subject was informed and voluntarily signed the informed consent form.
(1) Patients who had received revascularization within 1 month before enrollment, or who had required revascularization after this coronary angiography.
(2) Suffering from obvious liver and kidney diseases, or alanine aminase (ALT), aspartate amino transferase (AST) 1.5 times above the normal upper limit, creatinine (Cre), blood urea nitrogen (BUN) above the normal upper limit;
(3) Suffering from serious heart failure, myocardial heart disease, structural heart disease, difficult to control hypertension and other serious cardiovascular diseases;
(4) Patients with serious mental illness, hematopoietic diseases, malignant tumors and other major diseases;
(5) Pregnancy or preparation for pregnancy Women, lactating women;
(6) Participated in or are attending other clinical researchers in the past three months;
(7) A suspicious or clear allergy to the study drug.
(8) Other circumstances that the research physician does not consider unsuitable to participate in this trial, including but not limited to: the subjects are unable to follow the study protocol and will bring safety risks to the subjects.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Coronary flow reserve;Glycosylated hemoglobin;High sensitivity C-reactive protein;Coronary flow reserve fraction;Endothelial cell specific molecule-1;Serotonin;Ischemia modified albumin;Coronary microvascular resistance index;Triglyceride;Low density lipoprotein;High density lipoprotein;Serum soluble growth stimulating factor-2;Homocysteine;serum soluble CD40 ligand;
- Secondary Outcome Measures
Name Time Method Self rating Anxiety Scale;Self rating Depression Scale;TCM syndrome score;Seattle angina pectoris scale;