Physical and emotional well-being and cognitive functioning: the PREDICT-MR study

Completed

• Conditions: Depression; mood disorder. Cognitive impairment; 10027946; 10003216

• Registration Number: NL-OMON36665
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 250

Inclusion Criteria

1) All participants who were diagnosed with major depressive disorder in one or more measurements of the PREDICT study (03-177/O).
2) Participants without a diagnosis of major depressive disorder on any of the PREDICT measurements.
3) All PREDICT participants of 65 years or older.

Exclusion Criteria

Contra-indications for MRI scan (metals in the body, claustrophobia, pregnancy). Dementia, psychosis, terminally ill, or physically unable to come to the UMCU as diagnosed by the general practitioner of the participant.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Outcome variables for research question 1 are the volume of the hippocampus and<br /><br>total brain volume on MRI.<br /><br>Outcome variables for research question 2 are the small vessels on MRI.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Hypothalamic-pituitary-adrenal (HPA) axis, antidepressant medication, cognitive<br /><br>functioning.</p><br>