Hiperemezis and Serotonin Elevated Serum Serotonin Levels in Hyperemesis

• Conditions: Vomiting; Markedly Reduced Food Intake; Severe Dehydration; Nausea

• Registration Number: NCT01987869
• Lead Sponsor: Bakirkoy Dr. Sadi Konuk Research and Training Hospital

Brief Summary

Serotonin excretion was investigated in the nausea and vomiting associated with hiperemezis gravid arum.

Detailed Description

The occurrence of severe nausea and vomiting of early pregnancy (hiperemezis gravid arum) is estimated between 0.3% to 1% of all pregnancies. Although hiperemezis gravid arum has been recognized for a long time, its pathophysiologic mechanisms are still poorly understood. Many theories have been advocated, but to date none of these have been convincing.

It has been demonstrated that the nausea and vomiting associated with increased in serotonin liberation. This has provided a rationale for the treatment of these symptoms with specific serotonin antagonists.

The aim of this trial was to investigate the possible relationship between hiperemezis gravid arum and serotonin liberation.

Study Timeline

• Study Start: 2013-10
• Status Verified: 2013-11
• Study First Submitted: 2013-11-13
• Study First Submitted QC: 2013-11-18
• Last Update Submitted: 2013-11-18
• Study First Posted: 2013-11-19
• Last Update Posted: 2013-11-19
• Primary Completion: 2014-02
• Study Completion: 2014-03

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 90

Inclusion Criteria

• 6-14 week pregnant women
• nausea
• protracted vomiting
• inability to tolerate food intake accompanied by obvious dehydration
• severe enough to justify hospitalisation
• at least 2+ ketonuria on dipstick urinanalysis.

Exclusion Criteria

• with metabolic disorders such as diabet, thyroid

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
serum serotonin levels in hiperemezis gravidarum	6-14week pregnancy

Secondary Outcome Measures

Name	Time	Method
ıs there any assosiation between serotonin levels and severity of symptoms in pregnant women with hiperemezis	6-14week pregnancy

Trial Locations

Locations (1)

Bakirkoy Dr Sadi Konuk Training and Research Hospital; 🇹🇷 Istanbul, Turkey