Relationship Between Elevated Serum Serotonin Levels in Symptomatic Patients With Hyperemezis
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- serum serotonin levels in hiperemezis gravidarum
研究概览
简要总结
Serotonin excretion was investigated in the nausea and vomiting associated with hiperemezis gravid arum.
详细描述
The occurrence of severe nausea and vomiting of early pregnancy (hiperemezis gravid arum) is estimated between 0.3% to 1% of all pregnancies. Although hiperemezis gravid arum has been recognized for a long time, its pathophysiologic mechanisms are still poorly understood. Many theories have been advocated, but to date none of these have been convincing.
It has been demonstrated that the nausea and vomiting associated with increased in serotonin liberation. This has provided a rationale for the treatment of these symptoms with specific serotonin antagonists.
The aim of this trial was to investigate the possible relationship between hiperemezis gravid arum and serotonin liberation.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 15 Years 至 50 Years（Child, Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •6-14 week pregnant women
- •protracted vomiting
- •inability to tolerate food intake accompanied by obvious dehydration
- •severe enough to justify hospitalisation
- •at least 2+ ketonuria on dipstick urinanalysis.
排除标准
- •with metabolic disorders such as diabet, thyroid
结局指标
主要结局
serum serotonin levels in hiperemezis gravidarum
时间窗: 6-14week pregnancy
次要结局
- ıs there any assosiation between serotonin levels and severity of symptoms in pregnant women with hiperemezis(6-14week pregnancy)