Functional Connectivity (With fMRI) as an Objective Measure of Postoperative Cognitive Function in Elderly Fracture Hip Patients
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Postoperative Delirium
- Sponsor
- University of Florida
- Enrollment
- 2
- Locations
- 1
- Primary Endpoint
- Changes between baseline and follow up visits as assessed by fMRI
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
The long-term goal of this study is to evaluate cognitive function preoperatively and develop techniques of intervention in the perioperative period which would optimize brain function and functional recovery following surgery.
Detailed Description
In this protocol, subjects who are anticipated to be operated for hip fracture will be studied after surgery. Brief cognitive exam will be done followed by fMRI of connectivity and diffusion tensor imaging (DTI). Connectivity (neuronal changes) and DTI (Anisotropy and mean diffusivity) data will be compared with age matched controls and correlated with subjective measures of cognition.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients 65 years and older
- •Patients who have fracture hip and are anticipated to have surgery
Exclusion Criteria
- •Patients who have contraindications for MRI like pacemaker, automatic implanted cardiac defibrillator (AICD), implanted infusion pumps etc.
- •Patients who are claustrophobic
- •Patients with severe cognitive impairment (who may not be able to cooperate during the cognitive exam and fMRI)
Outcomes
Primary Outcomes
Changes between baseline and follow up visits as assessed by fMRI
Time Frame: Change from baseline up to 90 days
fMRI for measuring function connectivity and DTI
Secondary Outcomes
- Changes between baseline and follow up visits as assessed by Digital Clock Drawing Test Command and Copy(Change from baseline up to 90 days)
- Changes between baseline and follow up visits as assessed by Wide Range Achievement Test reading subtest(Change from baseline up to 90 days)
- Changes between baseline and follow up visits as assessed by MoCA(Change from baseline up to 90 days)
- Changes between baseline and follow up visits as assessed by HVLT(Change from baseline up to 90 days)