The Acute Effects of Brain Activation and Functional Connectivity Following Motor-cognitive Training Using Functional MRI
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Injury;Sports
- Sponsor
- Ke'La H Porter
- Enrollment
- 21
- Locations
- 1
- Primary Endpoint
- Change in brain activation
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
Participants will complete a functional MRI to evaluate brain activation, functional connectivity, and behavioral performance immediately before and after a training program (approximately 30 minutes). The training program will comprise of integrate neuromuscular (agility, dynamic postural stability, shuffling, rapid acceleration/deceleration, plyometrics, lateral shuffle, and core stability) and cognitive (reaction time, processing speed, task switching, decision-making, and working memory) challenges.
Investigators
Ke'La H Porter
Research Analyst Principal
University of Kentucky
Eligibility Criteria
Inclusion Criteria
- •Physically active
Exclusion Criteria
- •Injury to the muscle or bone (upper extremity, lower extremity, or back) within the past 3 months
- •Had musculoskeletal surgery or fracture (required open reduction internal fixation or within the last 12 months)
- •Had a concussion or mild head injury within the last year
- •Have been diagnosed with any kind of neurological, vestibular, or visual disturbance that impairs mobility
- •Currently taking medications that affect the central nervous system
- •Pregnant or suspicions of being pregnant
- •Have metal fragments, pins, plates, or clips, shrapnel, body piercings that cannot be removed, have surgical implants or orthodontics that cannot be removed
- •Have claustrophobia
- •Have a history of cognitive impairment
Outcomes
Primary Outcomes
Change in brain activation
Time Frame: 2 hours, pre-training session and immediately post-training session
During the task-based functional MRI scan the participant will complete a task-switching cognitive task, where participants have to identify two possible shapes (circle or square), in one of two possible colors (red or blue). They will respond using a trigger under their left and right foot. The level of brain activation during the task will be captured and reported.
Change in functional connectivity
Time Frame: 2 hours, pre-training session and immediately post-training session
The participant will complete a resting-state functional MRI scan in which they will lay still in the scanner. No task is performed during this scan. Functional connectivity (functionally related regions of the brain that are co-activated) during the scan will be captured and reported.
Change in reaction time
Time Frame: 2 hours, pre-training session and immediately post-training session
During the task-based functional MRI scan the participant will complete a task-switching cognitive task, where participants have to identify two possible shapes (circle or square), in one of two possible colors (red or blue). They will respond using a trigger under their left and right foot. The reaction time in milliseconds will be captured. The change in reaction time from pre to post training session will be reported.
Change in accuracy
Time Frame: 2 hours, pre-training session and immediately post-training session
During the task-based functional MRI scan the participant will complete a task-switching cognitive task, where participants have to identify two possible shapes (circle or square), in one of two possible colors (red or blue). They will respond using a trigger under their left and right foot. The percent of correct responses (accuracy) will be captured. The change in accuracy from pre to post training session will be reported.
Secondary Outcomes
- Modified Disablement In Physically Active Scale(Once, pre-training)
- NASA Physical Activity Survey(Once, pre-training)
- Defense Veterans Pain Rating Scale(Once, pre-training)
- Heart rate(35 minutes, during the training session)
- Average reaction time during the intervention(30 minutes, during the training session)
- Misses during the training session(30 minutes, during the training session)
- Perceived cognitive difficulty(30 minutes, during the training session)
- Demographic/Injury History Form(Once, pre-training)
- Number of errors during the training session(30 minutes, during the training session)
- Hits during the training session(30 minutes, during the training session)
- Rate of perceived exertion(30 minutes, during the training session)