The Effect of Ketone Monoester Supplementation and High Altitude on Exercising Cerebral Blood Flow
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 14
- 试验地点
- 2
- 主要终点
- Cerebral Blood Velocity
研究概览
简要总结
The purpose of this trial is to investigate the effect of acute ketone monoester ingestion (0.6 g KME/kg body weight) on the occurrence of the ventilatory threshold and the subsequent response of blood velocity in cerebral arteries during a maximal exercise test at low altitude and high altitude.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Must be a member of the research expedition team travelling to the Barcroft Research Station in White Mountain California
排除标准
- •BMI > 30
- •No prescribed medications (oral contraceptives excluded)
- •History of smoking
- •Currently following a ketogenic diet or consuming exogenous ketogenic supplements
- •History of heart, lung, blood vessel, or kidney disease
- •Currently pregnant
研究组 & 干预措施
High Altitude (3800m; Barcroft Research Station)
High altitude setting
干预措施: Ketone Monoester (KME) (Dietary Supplement)
High Altitude (3800m; Barcroft Research Station)
High altitude setting
干预措施: Placebo (Dietary Supplement)
Low Altitude (334m; University of Guelph)
Low altitude setting
干预措施: Ketone Monoester (KME) (Dietary Supplement)
Low Altitude (334m; University of Guelph)
Low altitude setting
干预措施: Placebo (Dietary Supplement)
结局指标
主要结局
Cerebral Blood Velocity
时间窗: 3 hours
Transcranial Doppler ultrasound will be used to measure blood velocity in the middle cerebral artery and posterior cerebral artery. Location of measurements will remain consistent within participants.
次要结局
- Ventilation(3 hours)
- Cardiac Output(3 hours)
- Blood Pressure(3 hours)
- Ventilatory Threshold(3 hours)
- End-Tidal Gases(3 hours)
- Rate of Oxygen Consumption and Carbon Dioxide Production(3 hours)
- Blood Lactate and Beta-Hydroxybutyrate(3 hours)
- Peak Work Rate (Maximal Exercise Test)(3 hours)
研究者
Jeremy Walsh
Assistant Professor
McMaster University