Thiopurines with Low Dose Allopurinol: a prospective one way cross-over study

Completed

• Conditions: Crohn; inflammatory bowel disease; 10017969

• Registration Number: NL-OMON42907
• Lead Sponsor: Meander Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 22

Inclusion Criteria

-Crohn's disease or Colitis Ulcerosa
-At least one month perior usage of 100 mg allopurinol daily with azathioprine or mercaptopurine
-Stable response and adequate concentrations on combination therapy with a thiopurine and allopurinol
-No recent (<1 month) changes in thiopurine dosage
-At least 18 years old

Exclusion Criteria

-Age below 18 years old
-Pregnancy
-Hypersensitivity to azathioprine, mercaptopurine and/or allopurinol
-Severe anemia, leukopenia or thrombocytopenia
-Lesch-Nyhan syndrome

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- 6-TGN and 6-MMP concentrations<br /><br>These are the metabolites of the thiopurine that is being used by a patient.<br /><br>The concentrations before and after the intervention will be measured with (a<br /><br>validated) UPLC-analysis.</p><br>