Health ImprOvement Program of Bone in China

Recruiting

• Conditions: Osteoporosis

• Registration Number: NCT05906147
• Lead Sponsor: Second Xiangya Hospital of Central South University

Brief Summary

Fracture risk factors have long been identified as key factors in osteoporosis and fragility fractures. The WHO recommended Fracture risk assessmenttool (FRAX) applies clinical risk factors to assess the absolute risk of osteoporotic fractures in each individual. Our preliminary study suggests that FRAX estimates may underestimate the risk of fractures in the Chinese population. In order to optimize the risk prediction model of osteoporotic fractures, a treatment threshold and its optimal cutting point were initially established based on the data of the health management Center of the Second Xiangya Hospital of Central South University.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-02-27
• Primary Completion: 2021-02-27
• Status Verified: 2023-06
• Study First Submitted: 2023-06-07
• Study First Submitted QC: 2023-06-07
• Last Update Submitted: 2023-06-07
• Study First Posted: 2023-06-15
• Last Update Posted: 2023-06-15
• Study Completion: 2031-02-27

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 5000

Inclusion Criteria

• Dual-energy X-ray bone mineral density measurement was performed in the health management center of our hospital in the physical examination subjects over 40 years old. Have independent civil capacity and agree to participate, and sign informed consent

Exclusion Criteria

• Under 40 years of age， Patients who had undergone hip replacement or lumbar surgery and could not perform dual-energy X-ray BMD testing; Patients who have been treated with effective anti-osteoporosis drugs or have a history of malignant tumors.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
clinical risk factors of osteoporotic fracture	From 2021 to 2031	The main clinical risk factors of osteoporotic fracture were collected
bone mineral density bone mineral density	From 2021 to 2031	Bone mineral density (BMD) data measured by dual-energy X-ray absorptiometry were collected from patients over 40 years old
Occurrence of fracture	From 2021 to 2031	Follow-up of the population was conducted to track the incidence of fractures

Trial Locations

Locations (1)

Health Management Center, The Second Xiangya Hospital of Central South University; 🇨🇳 Changsha, Hunan, China