Regional delivery of prophylactic antibiotics in total knee arthroplasty via an intraosseous routeA tissue penetration study

Not Applicable

Active, not recruiting

• Conditions: Surgery - Surgical techniques; Infected total knee arthroplasty

• Registration Number: ACTRN12611000001998
• Lead Sponsor: Middlmore Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2011-01-04
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Active, not recruiting
• Sex: All
• Target Recruitment: 22

Inclusion Criteria

Total Knee Replacement patients
Osteoarthritis
Body Mass Index (BMI)<30

Exclusion Criteria

Active infection
Impaired renal function
Allergiy to antibiotic

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Primary outcome is Cephazolin concentration in tissue. Seven samples will be taken from each patient, 4 fat samples and 3 bone samples. Each sample will be approximately the size of a pinhead. Bone samples will be taken from the femur only to ensure no direct contamination from the site of injection (tibia). Due to the small size of the samples it is anticipated that there will be no detrimental effect on the patient whatsoever. Samples will be stored at Middlemore hospital lab at -90 degrees Celsius, before being sent to Christchurch for analysis using a technique called high performance liquid chromatography (HPLC), which will determine the concentration of Cefazolin in each sample.[15 minute intervals post administration]

Secondary Outcome Measures

Name	Time	Method
il[Nil]