Randomised prospective, double-blinded study comparing the effectiveness of administering morphine patient controlled analgesia (PCA) to morphine and ketamine PCA for patients undergoing a total knee replacement.

Completed

• Conditions: Pain after Total Knee Replacement; Ketamine in patient controlled analgesia side effects; Morphine patient controlled analgesia side effects; Anaesthesiology - Pain management

• Registration Number: ACTRN12613001036707
• Lead Sponsor: Yoon Leng Ooi

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-09-18
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 530

Inclusion Criteria

Elective patients undergoing a Total Knee Replacement
18 years or older
Would be able to understand the use of a Patient Controlled Analgesia (PCA) system

Exclusion Criteria

An allergy to morphine or ketamine
Patient inability to use a PCA
Pre-existing neurological or psychiatric illnesses
Evidence of severe cardiovascular, renal, hematologic or hepatic disease
Patients unsuitable for the study’s standardised anaesthetic technique
Patients requiring other analgesic drugs or regional techniques which may affect the appreciation of pain
Alcohol and opioid dependent patients
Patients with a history of chronic pain

Study & Design

• Study Type: Interventional
• Study Design: Not specified