Optic Nerve and Retinal Functions With Bevacizumab

Completed

• Conditions: Choroidal Neovascular Membrane
• Interventions: Procedure: Electrophysiology

• Registration Number: NCT01361828
• Lead Sponsor: Cairo University

Brief Summary

The purpose of this study is to investigate the possible affection of optic nerve and retinal functions following intravitreal bevacizumab injection in human eyes.

Detailed Description

To evaluate the retinal and optic nerve functions of bevacizumab when injected intravitreal in human eyes using electrophysiological tests; Electroretinogram (ERG) and Visual Evoked Potentials (VEP). Forty five eyes of 45 patients with choroidal neovascular membrane (CNV) who were prepared for intravitreal injections of 1.25mg bevacizumab underwent baseline ERG and VEP in both eyes before, and at 1 and 4 weeks after the intravitreal injections.

Study Timeline

• Status Verified: 2010-01
• Study Start: 2010-01
• Primary Completion: 2010-07
• Study Completion: 2010-07
• Study First Submitted: 2011-05-26
• Study First Submitted QC: 2011-05-26
• Last Update Submitted: 2011-05-26
• Study First Posted: 2011-05-27
• Last Update Posted: 2011-05-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 45

Inclusion Criteria

• CNV

Exclusion Criteria

• Previous Intravitreal Injections

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients with choroidal neovascularization	Electrophysiology	CNV due to Age-Related Macular Degenerations and Myopia were included.

Primary Outcome Measures

Name	Time	Method
Visual Evoked Potential and Electroretinogram	4 weeks	VEP and ERG baseline and at 1 and 4 weeks post intravitreal injection of bevacizumab.

Trial Locations

Locations (1)

Cairo University; 🇪🇬 Cairo, --- Select One ---, Egypt