Do Markers of Systemic Inflammatory Response and Tumor Metabolism Indicate Radioresistance in Head and Neck Cancer?
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Survival
研究概览
简要总结
The aim of the study is to prospectively evaluate whether markers of a patient's systemic inflammatory response in addition to FDG-PET/CT metabolic parameters of the primary tumor or of nodal metastases can predict radioresistance and survival before primary radiochemotherapy in advanced head and neck cancer patients.
详细描述
This study prospectively investigates pretherapeutic markers of systemic inflammatory response (including neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, systemic inflammation response index, and systemic immune-inflammation) and FDG-PET/CT-derived metabolic parameters of tumor and nodal metastases (including maximum standardized uptake value, metabolic tumor volume, and total lesion glycolysis) and their potential prognostic value in head and neck cancer patients prior to primary radiochemotherapy.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •histopathologic diagnosis of squamous cell carcinoma of the head and neck
- •primary radio(chemo)therapy with curative intent
- •available pretherapeutic FDG-PET/CT imaging
- •available pretherapeutic differential blood analysis
排除标准
- •other tumor entities of the head and neck including cutaneous squamous cell carcinoma
- •primary surgical treatment
- •ongoing infections or other inflammatory diseases at the time of diagnosis
- •patients not completing a course of irradiation with at least 66 Gray locally
结局指标
主要结局
Survival
时间窗: Prospective analysis of various measures of survival up to 5 years after completion of the therapy. Events such as tumor recurrence or death will be recorded continually.
Overall survival, disease-specific survival, local and regional recurrence-free survival, and distant metastasis-free survival
次要结局
未报告次要终点