Systemic Inflammation Versus Acute Pain in Total Knee Arthroplasty (TKA)
Completed
- Conditions
- Systemic Inflammatory Response SyndromeOther Acute Postoperative Pain
- Registration Number
- NCT01322074
- Lead Sponsor
- Hvidovre University Hospital
- Brief Summary
In this study we evaluate if there is a correlation between acute pain and systemic inflammatory markers after total Knee Arthroplasty (TKA).
- Detailed Description
The correlation between acute pain and systemic inflammatory markers after total Knee Arthroplasty (TKA) is evaluated.
Level of systemic inflammatory markers (CRP and IL6) are measured preoperatively and 4 and 24 hours postoperatively. These measurements are correlated to postoperative pain (a detailed assessment of pain at rest and during ambulation).
We pole blood-samples collected prospectively (from two data set)
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 120
Inclusion Criteria
- Elective unilateral primary total knee arthroplasty
- Able to speak and understand danish
- Able to give informed consent
Exclusion Criteria
- Alcohol or medical abuse
- Allergies to local anesthetics or methylprednisolone
- Age < 18 years old
- Daily use of strong opioids or glucocorticoids
- Pregnancy or breastfeeding (fertile women)
- Bilateral / revision arthroplasty
- Dementia or other cognitive dysfunction
- Diabetic neuropathy, rheumatoid arthritis, and neurologic or psychiatric diseases potentially influencing pain perception
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Systemic inflammation vs. pain 1 week The correlation between pain and systemic inflammatory markers (CRP and IL6)
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Dep. of Anesthsiology, Hvidovre University Hospital
🇩🇰Copenhagen, Hvidovre, Denmark