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Clinical Trials/NCT01322074
NCT01322074
Completed
Not Applicable

The Relation Between Systemic Inflammatory Markers and Acute Pain in TKA

Hvidovre University Hospital1 site in 1 country120 target enrollmentAugust 2009
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ConditionsOther Acute Postoperative PainSystemic Inflammatory Response Syndrome

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Other Acute Postoperative Pain
Sponsor
Hvidovre University Hospital
Enrollment
120
Locations
1
Primary Endpoint
Systemic inflammation vs. pain
Status
Completed
Last Updated
14 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSitesSimilar Trials

Overview

Brief Summary

In this study we evaluate if there is a correlation between acute pain and systemic inflammatory markers after total Knee Arthroplasty (TKA).

Detailed Description

The correlation between acute pain and systemic inflammatory markers after total Knee Arthroplasty (TKA) is evaluated. Level of systemic inflammatory markers (CRP and IL6) are measured preoperatively and 4 and 24 hours postoperatively. These measurements are correlated to postoperative pain (a detailed assessment of pain at rest and during ambulation). We pole blood-samples collected prospectively (from two data set)

Registry
clinicaltrials.gov
Start Date
August 2009
End Date
October 2011
Last Updated
14 years ago
Study Type
Observational
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Troels Haxholdt Lunn

MD

Hvidovre University Hospital

Eligibility Criteria

Inclusion Criteria

  • •Elective unilateral primary total knee arthroplasty
  • •Able to speak and understand danish
  • •Able to give informed consent

Exclusion Criteria

  • •Alcohol or medical abuse
  • •Allergies to local anesthetics or methylprednisolone
  • •Age \< 18 years old
  • •Daily use of strong opioids or glucocorticoids
  • •Pregnancy or breastfeeding (fertile women)
  • •Bilateral / revision arthroplasty
  • •Dementia or other cognitive dysfunction
  • •Diabetic neuropathy, rheumatoid arthritis, and neurologic or psychiatric diseases potentially influencing pain perception

Outcomes

Primary Outcomes

Systemic inflammation vs. pain

Time Frame: 1 week

The correlation between pain and systemic inflammatory markers (CRP and IL6)

Study Sites (1)

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