NCT01322074已完成不适用
The Relation Between Systemic Inflammatory Markers and Acute Pain in TKA
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- Systemic inflammation vs. pain
研究概览
简要总结
In this study we evaluate if there is a correlation between acute pain and systemic inflammatory markers after total Knee Arthroplasty (TKA).
详细描述
The correlation between acute pain and systemic inflammatory markers after total Knee Arthroplasty (TKA) is evaluated.
Level of systemic inflammatory markers (CRP and IL6) are measured preoperatively and 4 and 24 hours postoperatively. These measurements are correlated to postoperative pain (a detailed assessment of pain at rest and during ambulation).
We pole blood-samples collected prospectively (from two data set)
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Elective unilateral primary total knee arthroplasty
- •Able to speak and understand danish
- •Able to give informed consent
排除标准
- •Alcohol or medical abuse
- •Allergies to local anesthetics or methylprednisolone
- •Age < 18 years old
- •Daily use of strong opioids or glucocorticoids
- •Pregnancy or breastfeeding (fertile women)
- •Bilateral / revision arthroplasty
- •Dementia or other cognitive dysfunction
- •Diabetic neuropathy, rheumatoid arthritis, and neurologic or psychiatric diseases potentially influencing pain perception
结局指标
主要结局
Systemic inflammation vs. pain
时间窗: 1 week
The correlation between pain and systemic inflammatory markers (CRP and IL6)
次要结局
未报告次要终点
研究者
Troels Haxholdt Lunn
MD
Hvidovre University Hospital
研究点 (1)
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