Causal test of right anterolateral prefrontal cortex (ralPFC) involvement in fear and response inhibition.

Recruiting

• Conditions: anxiety disorder; fear regulation; 10002861

• Registration Number: NL-OMON45731
• Lead Sponsor: niversiteit Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 12 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 56

Inclusion Criteria

- Age between 18 and 45.
- Right-handedness.
- Written informed consent.

Exclusion Criteria

Violation of standard TMS safety criteria (Rossi, Hallett, Rossini, & Pascual-Leone, 2009; see also Appendix F1.1: TMS screenings questionnaire):
- Incapability of giving an informed consent
- Ferrous objects in or around the head (e.g. braces, pacemaker, metal fragments)
- History of closed- or open-head injury
- History of epilepsy
- History of epilepsy in first-degree relatives
- History of neurological or psychiatric illness
- Major medical history
- Drug or alcohol abuse over a period of six months prior to the experiment
- Pregnancy

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameter for study 1 is the effect of TMS stimulation on the<br /><br>reduction in FPS at offset of a threat cue, for study 2 the increase in SSRT<br /><br>(behaviourally) and concomitant decrease of N1 (derived from the EEG).</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>N/A.</p><br>