Effects of early, combined endurance and resistance training on mechanically ventilated, critically ill patients – a randomised controlled trial

Not Applicable

• Conditions: Intensive Care Unit Aquired Weakness; G62.80; G72.80

• Registration Number: DRKS00004347
• Lead Sponsor: niversitätsklinik für IntensivmedizinInselspital, Universitätsspital Bern

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2012-09-10
• Study Completion: 2016-10-08
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 115

Inclusion Criteria

=18 years
expected mechanical ventilation for >72 hours on a interdisciplinary intensive care unit
qualitatively independent before illness

Exclusion Criteria

contraindication for bedside ergometer MOTOmed
weight > 150kg
preexisting neuromuscular / neurological disease with enduring functional limitations
former hospital stay of more than 10 days
limited therapy because of expected poor outcome
inclusion in other intervention study
admission diagnosis that makes a walking test at hospital discharge impossible

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The functional exercise capacity using the 6 Minute Walking Test<br>The independence during activities of daily living measured with the Functional Independence Measure.<br>Both assessments are evaluated at the time of hospital discharge.

Secondary Outcome Measures

Name	Time	Method
Muscle Force (precondition: patient follows 3 of 5 commands)<br>- Medical Research Council sum score (MRC) for 6 muscle groups<br>- handgrip force using the JAMAR Dynamometer<br>- quantitiv muscle force of the Quadriceps using a Hand Held Dynamometer<br>Tests from day 7 (follow-up every 14 days) and at ICU discharge.<br><br>Joint mobility, Range of motion using a Goniometer and the Neutral-0-Method.<br>Tests from day 7 and at ICU discharge.<br><br>Functional exercise capacity using the Timed-Up-And-Go Test at hospital discharge.<br><br>Length of stay in the ICU and hospital, achieved milestones during the ICU.<br><br>Quality of live, using the Short Form36, 6 months after hospital discharge.<br><br>