Evaluation of effect of Dexmedetomidine on Succinylcholine induced fasciculations and myalgia in patients undergoing electroconvulsive therapy

The study aims to investigate if Dexmedetomidine affects succinylcholine induced myalgia and fasciculations in psychiatric patients undergoing electroconvulsive therapy.Patients are randomly allocated into 2 groups - Group C (control) and group D(dexmedetomidine) using computer generated sequence. Patients are explained about grading of pain.

Patients in the control group are given 10 ml normal saline IV. Patients in the dexmedetomidine group are given dexmedetomidine 0.25 mcg/kg IV diluted in 10 ml normal saline.Patients are shifted to the ECT room. Monitors are attached for continually monitoring heart rate, blood pressure, oxygen saturation. An IV line is secured.

Patients in the dexmedetomidine group are given IV dexmedetomidine 0.25 mcg/kg diluted in 10 ml normal saline over 10 minutes. Patients in the control group are administered 10 ml normal saline.Patients are preoxygenated with 100% oxygen. Patients are administered Inj glycopyrrolate 0.2 mg IV. IV induction is done using Inj propofol 1 mg/kg IV and Inj succinylcholine 1.5 mg/kg IV. Fasciculations are noted and graded using Mingus scale. Patients are ventilated using bag and mask. An electrical stimulus is applied through the scalp

electrodes after ensuring complete paralysis. Bag and mask ventilation is initiated after cessation of seizure activity in electroencephalogram until the patient’s spontaneous breathing is sufficient. Myalgia is measured 30 mins after the procedure using self reported myalgia scores developed by Harvey et al. Inj Paracetamol 1 g IV is given to patients with pain score of 2 or more (scale

by Harvey et al).