The Effects of Whole Body Vibration in People With Chronic Stroke

Not Applicable

Completed

• Conditions: Stroke
• Interventions: Procedure: High frequency whole body vibration; Procedure: Low frequency whole body vibration

• Registration Number: NCT03982251
• Lead Sponsor: The Hong Kong Polytechnic University

Brief Summary

Whole body vibration (WBV) has been found to be useful in promoting bone health and muscle performance in older adults. To date, no study has examined the effects of different WBV frequencies on the properties of the muscle-bone unit in stroke patients. The overall aim of the proposed study is to compare the efficacy of different vibration frequencies on properties of the muscle function and bone turnover among people with chronic stroke.

It is hypothesized that the higher-vibration frequency protocol will lead to significantly better outcomes related to the bone turnover and muscle function.

Detailed Description

Whole body vibration (WBV) has been found to be useful in promoting bone health and muscle performance in older adults. To date, no study has examined the effects of different WBV frequencies on the properties of the muscle-bone unit in stroke patients. The overall aim of the proposed study is to compare the efficacy of different vibration frequencies on properties of the muscle function and bone turnover among people with chronic stroke.

It is hypothesized that the higher-vibration frequency protocol will lead to significantly better outcomes related to the bone turnover and muscle function in people with chronic stroke.

Study Timeline

• Study Start: 2017-06-28
• Primary Completion: 2018-06-28
• Study Completion: 2018-08-28
• Status Verified: 2019-06
• Study First Submitted: 2019-06-06
• Study First Submitted QC: 2019-06-09
• Last Update Submitted: 2019-06-09
• Study First Posted: 2019-06-11
• Last Update Posted: 2019-06-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

1. a diagnosis of stroke
2. stroke onset >6 months
3. >18 years of age
4. able to walk for short distance independently with or without walking aid
5. able to understand simple verbal commands

Exclusion Criteria

1. neurological conditions other than stroke
2. significant musculoskeletal conditions (e.g. amputations)
3. metal implants in the lower extremity
4. previous fracture of the lower extremity
5. are currently taking bone resorption inhibitors or were taking the same before stroke.
6. significant peripheral vascular disease
7. vestibular disorders
8. pregnancy
9. Other serious illnesses that preclude the person from participating in the study

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
High frequency whole body vibration	High frequency whole body vibration	This group will receive a single 8-minute session of WBV therapy. The frequency of the vibration signals will be set at 30Hz.
low frequency whole body vibration	Low frequency whole body vibration	This group will receive a single 12-minute session of WBV. The frequency of the vibration signals will be set at 20 Hz.

Primary Outcome Measures

Name	Time	Method
bone resorption marker	post-test (week8)	Serum level of aminoterminal crosslinked telopeptide

Secondary Outcome Measures

Name	Time	Method
Spasticity	post-test (week8)	H-reflex on tibial nerve and modified ashworth scale
Gait velocity	post-test (week8)	10-meter walking test
Six Minute Walk Test	post-test (week8)	endurance Test

Trial Locations

Locations (1)

The Hong Kong Polytechnic University; 🇭🇰 Hongkong, Hong Kong