NCT03863171Unknown不适用
Early Diagnosis for Ocular Ischemia Syndrome Using Arterial Spin Labeling Magnetic Resonance Imaging Technique: a Prospective Multicenter Cohort Study
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 190
- 试验地点
- 1
- 主要终点
- Blood Flow (BF)
研究概览
简要总结
- To evaluate ocular blood perfusion status and the possibility of craniocerebral vascular lesions of patients with ocular ischemia syndrome (OIS) using arterial spin labeling (ASL) magnetic resonance imaging technique.
- To evaluate the specificity, sensitivity and accuracy of arterial spin labeling (ASL) magnetic resonance imaging technique in OIS diagnosis, compared with the traditional routine examination method.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 50 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Ocular ischemia syndrome group: Patients diagnosed with ocular ischemia syndrome;
- •Age-related macular degeneration group (Control group): Patients diagnosed with age-related macular degeneration;
- •Age: 50-80 years;
- •Sex: all;
- •Patients signed written informed consent.
排除标准
- •Fundus fluorescein angiography (FFA) clear images cannot be obtained due to refractive media problems(such as corneal leukoplakia, severe cataract, vitreous hemorrhage, etc.) ;
- •Patients with contraindications for FFA;
- •Patients was unable to perform magnetic resonance rmaging (MRI) test;
- •Patients with history of bleeding and cerebral infarction;
- •Patients with a history of surgery within 3 months;
- •Patients who had participated in other clinical trials within 3 months;
- •Patients who disagree and refuse to participate in the trial.
结局指标
主要结局
Blood Flow (BF)
时间窗: through study completion, an average of 2 years
Blood Flow (BF)：a parameter measured by arterial spin labeling perfusion MRI to qualify the perfusion in tissue-specific units (ml blood/gram tissue/time)
次要结局
未报告次要终点
研究者
Yue Li
Clinical Professor
Beijing Friendship Hospital
研究点 (1)
Loading locations...
相似试验
Unknown
不适用
Retinal Vascular Changes in Primary Open Angle Glaucoma PatientsPrimary Open Angle GlaucomaNCT05351307Sohag University100
已完成
不适用
Retinal Microvasculature Before and After Silicone Oil by OCTARetinal VascularNCT04928196Kasr El Aini Hospital30
已完成
不适用
NA-AION Risk Factors: New PerspectivesNon-arteritic Ischemic Optic NeuropathyOptic Disk DrusenNCT05305079Rigshospitalet, Denmark179
已完成
不适用
Endothelial Dysfunction and DiabetesType 1 Diabetes MellitusNCT01097551Assistance Publique - Hôpitaux de Paris38
已完成
不适用
Clinical and Pathophysiological Description of Ocular Ischemic SyndromeDiabetic RetinopathyRetinal DegenerationNCT00403195Glostrup University Hospital, Copenhagen13