Noradrenaline Infusion Versus Phenylephrine Infusion in Improving Serum Lactate Level in HIPEC

Not Applicable

Completed

• Conditions: Hyperthermic Intraperitoneal Chemotherapy (HIPEC)
• Interventions: Drug: NORADRENALIN; Drug: PHENYLEPHRINE

• Registration Number: NCT04144465
• Lead Sponsor: Suez Canal University

Brief Summary

ABG PARAMETERS ARE CHANGED DURING HIPEC, WE TRIED TO FIND COMPARISON BETWEEN NORADRENALINE AND PHENYLEPHRINE IN OPTIMIZING ABG PARAMETERS THAT REFLECTS ORGAN PERFUSIONS ESPECIALLY SERUM LACTATE

Detailed Description

Arterial blood gas testing is considered one of the most important and widely used test in the detection of acidosis, alkalosis, electrolytes disturbance and tissue perfusion. in regard to tissue perfusion serum lactate above 4 mmol/L indicates poor tissue perfusion. serum lactate could be measured at ABG or separately. in this study we will test the effect of both noradrenaline and phenylephrine on lactate level at ABG during the stage of HIPAC in managing abdominal cancer patients.

Study Timeline

• Study First Submitted: 2019-10-19
• Study First Submitted QC: 2019-10-29
• Study First Posted: 2019-10-30
• Study Start: 2019-11-01
• Primary Completion: 2023-10-30
• Study Completion: 2023-12-30
• Status Verified: 2024-05
• Last Update Submitted: 2024-05-27
• Last Update Posted: 2024-05-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• CANCER PATIENTS ENROLLED FOR HIPEC

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Exclusion Criteria

• DRUG SENSITIVITY

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
NORADRENALIN	NORADRENALIN	NORADRENALINE INFUSION
PHENYLEPHRINE	PHENYLEPHRINE	PHENYLEPHRINE INFUSION

Primary Outcome Measures

Name	Time	Method
SERUM LACTATE IN ABG	IMMEDIATELY POSTOPERATIVELY	LANDMARK FOR TISSUE AND ORGAN PERFUSION

Trial Locations

Locations (1)

Suez Canal University; 🇪🇬 Ismailia, Egypt