The effect of bolus injection of phenylephrine and norepinephrine in preventing hypotension after spinal anesthesia in patients undergoing elective cesarean elective.
- Conditions
- Complications of anesthesia during the puerperium.Complications of anesthesia during the puerperium
- Registration Number
- IRCT20080921001264N13
- Lead Sponsor
- Gorgan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Female
- Target Recruitment
- 90
The participants in this study include pregnant women, 36 to 41 weeks, between 18 and 45 years old, who referred to Sayad Shirazi Hospital in Gorgan.
These patients are candidates for elective Cesarean elective
Do not have any restrictions for spinal anesthesia such as patient's lack of consent, sensitivity to anesthesia, injection site infection, and high intracerebral pressure.
Patients who enter the study in case of failure of spinal anesthesia, unpredictable complications during surgery, such as bleeding during surgery more than normal for a cesarean section without problems (more than 1500 ml) and the sensory level of T4 is higher than are excluded from the study.
At the beginning of the study, patients with uncontrolled heart complications, high blood pressure disorders in pregnancy, diabetes, psychiatric and renal problems, systolic blood pressure less than 90 mm Hg, peripheral bleeding, coagulation disorders
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method In the first few minutes after the injection of both drugs, we expect an increase in blood pressure, and we also expect to maintain the heart rate after the use of norepinephrine. Timepoint: It was monitored every 2 minutes to 6 minutes, every 3 minutes to 15 minutes and every 5 minutes until the end of the surgery. Method of measurement: An increase in blood pressure was calculated as an increase in systolic pressure greater than 120% of baseline and a drop in blood pressure was calculated based on a decrease in systolic blood pressure below 80% of baseline.
- Secondary Outcome Measures
Name Time Method Due to the short half-life of the drug, which is up to 3 minutes, and its metabolite is also inactive, we do not expect secondary effects. Timepoint: 5 minutes later. Method of measurement: In this study, an increase in blood pressure is calculated as an increase in systolic pressure more than 120% of the baseline, and a drop in blood pressure is calculated based on a decrease in systolic blood pressure below 80% of the baseline.