A glass of beetroot juice a day beats the exercise blues?

Not Applicable

Completed

• Conditions: Obesity; Heart Disease; Cardiovascular - Other cardiovascular diseases; Diet and Nutrition - Obesity

• Registration Number: ACTRN12616001608459
• Lead Sponsor: John Hunter Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-11-21
• Last Update Posted: 14 June 2021

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

Males and females
BMI greater or equal to 30kg/m2
20 to 60 years of age

Exclusion Criteria

1. Unable to provide written informed consent to participate in this study
2. Individuals who are receiving current anti-platelet therapy,
3. Known diabetes mellitus and the use of medication that might affect blood pressure, glucose or lipid metabolism will be excluded
4. Known heart disease
5. Concomitant conditions potentially limiting exercise capacity (eg peripheral vascular disease, respiratory, neuromuscular or orthopaedic disease states).

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The primary end-point will be the impact of beetroot juice on exercise capacity, assessed by Maximal-Effort Cardiopulmonary Exercise Test and a Constant-Intensity Protocol Cardiopulmonary Exercise Test [8 weeks post commencement]

Secondary Outcome Measures

Name	Time	Method
Secondary outcomes will assess impact of beetroot juice supplementation on markers of insulin sensitivity and glucose homeostasis (composite) assessed on blood tests<br>[8 weeks post commencement];Secondary outcomes will assess impact of beetroot juice supplementation on markers of endothelial function assessed by applanation tonometry[8 weeks post commencement];Secondary outcomes will assess impact of beetroot juice supplementation on skeletal muscle mitochondrial function. Small sample of skeletal muscle will be obtained by fine needle biopsy, mitochondria will be isolated and function measured as described by Sverdlov et al, J Am Heart Assoc 2016; 5(1). pii: e002555[8 weeks post commencement];Secondary outcomes will assess impact of beetroot juice supplementation on markers of inflammation assessed on blood tests<br>[8 weeks post commencement]