Effects of a Multiple Component Training Program on Muscles in Adults With Myotonic Dystrophy Type 1
- Conditions
- Myotonic Dystrophy 1
- Interventions
- Other: Training program
- Registration Number
- NCT04001920
- Lead Sponsor
- Cynthia Gagnon
- Brief Summary
A strength and endurance training program was conducted in adults with myotonic dystrophy type 1 (DM1). Participants underwent a 12-week/18-session supervised training program consisted of 6 exercises: elbow flexion/extension, shoulder horizontal adduction, leg press, and knee flexion/extension. To offer a complete training program aimed at improving function it was divided: the first 6 weeks were dedicated to strength-training, whereas the following weeks focused on endurance-training. To evaluate the effects of the training program, participants completed maximal strength, endurance and functional evaluations. Volunteers could also add a muscle biopsy at the beginning and the end of the program to evaluate physiological parameters.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 11
- Adults with DM1
- Walk without technical aid
- Muscle impairment rating scale (MIRS) of 3 or 4
- Severe musculoskeletal disorders
- Any medical contraindication to physical exercise
- Any medical contraindication to muscle biopsies for the biopsy volunteers
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Training program Training program 12-week strength and endurance training program
- Primary Outcome Measures
Name Time Method Change in maximal muscle strength in the knee extensors measured by quantified muscle testing Before and after the 12-week training program Changes in knee extensor maximal muscle strength evaluated by quantified muscle testing with a handheld dynamometer.
- Secondary Outcome Measures
Name Time Method Changes in muscle biopsy-leucocyte infiltration Before and after the 12-week training program for volunteers To assess changes in muscle fiber leucocyte infiltration
Change in 6 minute walking test disance Before and after the 12-week training program Walking endurance change measured by the 6 minute walking test distance.
Changes in quality of life measured by the 36-Item Short Form Survey (SF-36) Before and after the 12-week training program 36-item quality of life questionnaire. The final score is calculated on a total of 100 where the lower the score, the more disability. A score of 100 means no disability.
Changes in muscle biopsy-muscle fiber size Before and after the 12-week training program for volunteers To assess changes in muscle fiber size
Changes in functional capacity measured by the UQAM-YMCA test Before and after the 12-week training program Functional capacity evaluated by 18 functional tests
Changes in sprint capacity measured by the Running-base anaerobic sprint test Before and after the 12-week training program Sprint capacity changes measured by the running-base anaerobic sprint test
Changes in stumbles and falls measured by the Falls efficacy scale Before and after the 12-week training program 10-item questionnaire about stumbles and falls. All items are rated on a 10-point scale. A higher score means a higher fear of falling. A score over 70 means a significant fear of falling.
Changes in daytime sleepiness measured by the Daytime sleepiness scale (Epworth Sleepiness Scale) Before and after the 12-week training program 8-item questionnaire, rated on a scale from 0 to 3 for each item, the higher the score, the more the patient has daytime sleepiness.
Changes in life habits measured by questionnaire Before and after the 12-week training program Life habits questionnaire Assessment of life habits is a 77-item questionnaire with a scale from 0 to 9 for each item. A higher score means no disability and a low score means more disability.
Changes in muscle biopsy-proportion of centrally nuclated fibers Before and after the 12-week training program for volunteers To assess changes in muscle centrally nucleated fibers proportion
Changes in fatigue measured by the Fatigue severity scale Before and after the 12-week training program Fatigue questionnaire: 9-item questionnaire rated on a scale from 1 to 7 for each item. A score a higher score means more fatigue.
Changes in muscle biopsy-muscle fiber typing Before and after the 12-week training program for volunteers To assess changes in muscle fiber typing
Trial Locations
- Locations (1)
Groupe de recherche interdisciplinaire sur les maladies neuromusculaires
🇨🇦Saguenay, Quebec, Canada