Expression of FosB Gene in Laryngeal Cancer Tissues and It's Clinical Prognosis Significance
Trial Snapshot
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- the number of fosb gene positive expression cases in laryngeal carcinoma cells and adjacent tissues was determined.
Study Overview
Brief Summary
To determine whether there is statisstical difference in FosB (FBJ murine osteosarcoma viral oncogene homolog B) protein expression between laryngeal cancer tissue and adjacent tissue through immunohistochemistry methods.
If there are differences, further the investigators will collect relevant patients information,such as clinical stages, pathological types, clinical prognosis and so on. ultimately analyze whether it is related to the expression of FOsB in laryngeal cancer tissue and adjacent tissues
Detailed Description
First,the investigators will collect 100 to 200 cases of laryngeal cancer patients who have been finally diagnosed and treated in our institution in the past five years. Laryngeal cancer pathological tissues and adjacent tissues will be selected to make pathological sections. Use immunohistochemistry to confirm the differences in FosB protein between laryngeal cancer tissues and adjacent tissues, and clarify whether there are differences.
secondly,if there are differences, further the investigators will collect relevant patients information,such as clinical stages, pathological types, clinical prognosis and so on. Review the clinical data of corresponding patients, including age, gender, smoking and alcohol history, clinical stages, pathological types and clinical prognosis, etc., and compare whether there are statistical differences.
Finally, clinical prognostic data of relevant patients were collected through outpatient follow-up, online and telephone follow-up, to determine whether there is a correlation between Fosb expression in laryngeal cancer tissue and clinical prognosis.
Study Design
- Study Type
- Observational
- Observational Model
- Other
- Time Perspective
- Other
Eligibility Criteria
- Ages
- 35 Years to 90 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •laryngeal squamous cell carcinoma was diagnosed ,and biopsy was confirmed by two pathologists;
- •Primary tumor of Laryngeal ,and there was no distant metastasis;
- •Standard treatment such as surgery and Preliminarily-diagnosed parients;
- •full clinical and pathological data information and good follow-up;
- •there was no previous fatal diseases such as complicated tumors.
Exclusion Criteria
- •Secondary cancer or cancer with distant metastasis;
- •Patients who have not seen a doctor for the first time or have received surgery or radiotherapy or chemotherapy in other hospitals;
- •Clinical and pathological data were missing and loss to follow-up;
- •Patients who abandoned treatment or standard treatment procedures has not been completed;
- •The past medical history of other lethal diseases such as complicated tumors.
Outcomes
Primary Outcomes
the number of fosb gene positive expression cases in laryngeal carcinoma cells and adjacent tissues was determined.
Time Frame: one month
the number of fosb gene positive expression cases in laryngeal carcinoma cells and adjacent tissues was determined by immunohistochemical test of pathological sections.
Secondary Outcomes
- _Experimental result of western blot and PCR._Correlation analysis data between clinical information and experimental results..(three months)
Investigators
Yang ji
associate professor
Neijiang No.2 People's Hospital