Protein Expression Profiles in Oropharyngeal Squamous Cell Carcinoma
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 54
- 主要终点
- Development of biomarkers for early detection or recurrence surveillance
研究概览
简要总结
RATIONALE: Studying the proteins expressed in samples of tumor tissue from patients with cancer may help doctors identify and learn more about biomarkers related to cancer. It may also help doctors plan better treatment for patients with cancer of the oropharynx.
PURPOSE: This laboratory study is looking at protein expression in tumor tissue samples from patients with cancer of the oropharynx.
详细描述
OBJECTIVES:
- To investigate if some of the differences in gene expression are also reflected at the protein level.
- To determine whether differences in gene expression that are also reflected at the protein level can be used to develop markers for early detection and disease surveillance.
- To identify targets for therapy.
OUTLINE: Archived tumor tissue samples are analyzed for expression of standard immunohistological markers (e.g., p16, p53, and Ki-67) as well as expression of genes identified in a previous gene expression study. Protein expression data are tested for clinical and demographic correlates and compared with gene expression data.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of squamous cell carcinoma of the oropharynx
- •Tumor tissue samples available from Vanderbilt Head and Neck Tumor Repository and Vanderbilt Pathology archives
排除标准
- •Not specified
- •PRIOR CONCURRENT THERAPY:
- •Not specified
结局指标
主要结局
Development of biomarkers for early detection or recurrence surveillance
时间窗: after 7 months of tissue collection
Identification of therapeutic targets and individualization of treatment based on the biology of squamous cell carcinoma of the oropharynx
时间窗: after 7months of tissue collection
次要结局
未报告次要终点
研究者
Barbara Murphy, MD
Professor of Medicine, Medical Oncologist
Vanderbilt-Ingram Cancer Center