NCT00918892已完成不适用
Assessment of Candidate Protein Expression in Human Breast Cancer Specimens
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 460
- 试验地点
- 1
- 主要终点
- Differential expression of candidate genes between normal and cancer breast tissues
研究概览
简要总结
RATIONALE: Studying the genes expressed in samples of tumor tissue from patients with cancer may help doctors identify biomarkers related to cancer.
PURPOSE: This research study is looking at tumor tissue samples from patients who have undergone surgery for breast cancer.
详细描述
OBJECTIVES:
- To determine if candidate genes display differential expression between normal and cancer breast tissues.
OUTLINE: Previously collected breast cancer tissue samples (paraffin embedded blocks) and normal adjacent tissue are used for immunohistochemistry studies of expression of candidate genes.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •DISEASE CHARACTERISTICS:
- •Diagnosis of breast cancer
- •Tissue samples available
- •Samples are selected based on presence or absence of tumor receptors, (i.e.; estrogen, progesterone, and HER2 receptors) and grouped into following 4 categories:
- •Estrogen receptor (ER)-positive/progesterone receptor (PR)-positive/HER2-negative
- •ER-positive/PR-positive/ HER2-positive by FISH
- •ER-negative/PR-negative/HER2-positive
- •ER-negative/PR-negative/HER2-negative(triple negative or basal-type cancers)
- •PATIENT CHARACTERISTICS:
- •Menopausal status not specified
- •PRIOR CONCURRENT THERAPY:
- •Not specified
排除标准
- •There are no exclusion criteria in this protocol
结局指标
主要结局
Differential expression of candidate genes between normal and cancer breast tissues
时间窗: non-applicable
Approximately 5 slides of each tumor will be collected to provide sufficient samples for replicate staining, if necessary, as well as a staining for a positive control
次要结局
未报告次要终点
研究者
研究点 (1)
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