Analysis of Intersectin Expression in Primary Human Neuroblastomas
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Neuroblastoma
- Sponsor
- Children's Oncology Group
- Enrollment
- 20
- Primary Endpoint
- ITSN1 is highly expressed in neuroblastoma tumors and plays an important role in the development/progression of these tumors
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
RATIONALE: Studying protein expression in samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors find better ways to treat neuroblastoma.
PURPOSE: This laboratory studying is looking at protein expression in tumor tissue samples from patients with neuroblastoma.
Detailed Description
OBJECTIVES: * To determine whether intersectin (ITSN1) proteins are present at elevated levels in primary human tumor samples. OUTLINE: Archived tumor tissue samples are analyzed for intersectin (ITSN1) expression by western blot assays with enhanced chemiluminescence and exposed to X-ray film. The films are scanned, and levels of ITSN1 signal are quantified by densitometry.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
ITSN1 is highly expressed in neuroblastoma tumors and plays an important role in the development/progression of these tumors