Protein Expression in Human Neuroblastoma Tumor Samples

Completed

• Conditions: Neuroblastoma

• Registration Number: NCT01407731
• Lead Sponsor: Children's Oncology Group

Brief Summary

RATIONALE: Studying protein expression in samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors find better ways to treat neuroblastoma.

PURPOSE: This laboratory studying is looking at protein expression in tumor tissue samples from patients with neuroblastoma.

Detailed Description

OBJECTIVES:

* To determine whether intersectin (ITSN1) proteins are present at elevated levels in primary human tumor samples.

OUTLINE: Archived tumor tissue samples are analyzed for intersectin (ITSN1) expression by western blot assays with enhanced chemiluminescence and exposed to X-ray film. The films are scanned, and levels of ITSN1 signal are quantified by densitometry.

Study Timeline

• Study Start: 2011-07
• Study First Submitted: 2011-07-30
• Study First Submitted QC: 2011-07-30
• Study First Posted: 2011-08-02
• Status Verified: 2016-05
• Primary Completion: 2016-05
• Study Completion: 2016-05
• Last Update Submitted: 2016-05-13
• Last Update Posted: 2016-05-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
ITSN1 is highly expressed in neuroblastoma tumors and plays an important role in the development/progression of these tumors