Evaluating Candidate Protein Expression in Human Rhabdomyosarcoma (RMS)
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Sarcoma
- Sponsor
- Children's Oncology Group
- Enrollment
- 77
- Primary Endpoint
- RMS protein expression profile
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
RATIONALE: Studying tissue samples from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors find better ways to treat cancer.
PURPOSE: This research trial studies protein expression in samples from young patients with rhabdomyosarcoma.
Detailed Description
OBJECTIVES: * To measure the protein expression of candidate proteins in human rhabdomyosarcoma (RMS) tumor samples. OUTLINE: Archived tumor tissue samples are analyzed for protein expression (i.e., Notch1, Hey1, FGFR4, and Sp1) by IHC techniques and standard commercially available antibodies. Candidate proteins are then correlated with each patient age, gender, rhabdomyosarcoma (RMS) tumor stage, and RMS tumor subtype.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
RMS protein expression profile