Investigation to Evaluate the Levels of Human Germinal-center-Associated Lymphoma (HGAL) Protein in Pediatric Hodgkin Lymphoma and Correlate With Early Response
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 23
- 主要终点
- Variability of HGAL protein expression in pediatric patients with low-risk classical Hodgkin lymphoma (cHL)
研究概览
简要总结
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors identify and learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors predict how patients will respond to treatment.
PURPOSE: This research trial is studying protein biomarker levels in tissue samples from young patients with low-risk Hodgkin lymphoma.
详细描述
OBJECTIVES:
- To investigate the variability of expression of human geminal-center-associated lymphoma (HGAL) protein in pediatric low-risk Hodgkin lymphoma.
- To assess the variability of HGAL staining between risk groups by comparing samples from subjects enrolled in the low-risk study AHOD0431 with subject samples enrolled in AHOD0031 for intermediate-risk classical Hodgkin Lymphoma (cHL).
- To assess the variability of HGAL staining by evaluating a tissue array created from subjects with intermediate-risk cHL.
- To correlate rapid or slow early-response in the intermediate-risk group with HGAL protein expression.
OUTLINE: Paraffin-embedded tissue samples and tissue microarrays are analyzed for protein expression by IHC.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- — 至 21 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Variability of HGAL protein expression in pediatric patients with low-risk classical Hodgkin lymphoma (cHL)
Variability of HGAL staining between low-risk and intermediate-risk pediatric patients with cHL
Variability of HGAL staining as assessed by tissue array in pediatric patients with intermediate-risk cHL
Correlation of rapid or slow early response in the intermediate-risk group with HGAL protein expression
次要结局
未报告次要终点