NCT00899860终止不适用
Renal Cell Cancer Tumor Markers
适应症
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Correlation of gene and protein expression levels with disease stage, tumor size, and pathology reports
研究概览
简要总结
RATIONALE: Studying the genes and proteins expressed in tissue samples from patients with cancer may help doctors identify biomarkers related to cancer.
PURPOSE: This laboratory study is evaluating gene and protein expression in normal tissue and tumor tissue from patients who have undergone surgery for kidney cancer.
详细描述
OBJECTIVES:
Primary
- Determine the expression levels of novel genes and proteins (HFARP, HAMGR28, HE9NG77) in frozen normal tissue and tumor tissue samples from patients who have undergone nephrectomy for renal cell cancer.
- Correlate gene and protein expression levels with disease stage, tumor size, and pathology reports (e.g., cell type, grade, and tissue architecture) in order to evaluate the rate of gene and protein expression as targets for future therapeutic interventions.
Secondary
- Compare proteomic screening of potential biomarkers using existing plasma and/or urine samples from patients with renal cell cancer or breast cancer stored in the CCCWFU Tumor Tissue Core with tissue samples from patients enrolled in this study.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- — 至 120 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Histologically confirmed renal cell cancer
- •Clinical staging (if available)
- •Underwent nephrectomy for renal cell cancer
排除标准
- 未提供
结局指标
主要结局
Correlation of gene and protein expression levels with disease stage, tumor size, and pathology reports
时间窗: day 1
Expression levels of novel genes and proteins (HFARP, HAMGR28, HE9NG77) in frozen normal tissue and tumor tissue
时间窗: day 1
次要结局
- Comparison of proteomic screening of potential biomarkers using plasma and/or urine samples from patients with renal cell cancer or breast cancer stored in the CCCWFU Tumor Tissue Core with tissue samples from patients enrolled in this study(day 1)
研究者
研究点 (1)
Loading locations...
相似试验
已完成
不适用
Assessment of Candidate Protein Expression in Breast Cancer SpecimensBreast CancerNCT00918892Case Comprehensive Cancer Center460
已完成
不适用
Novel Prognostic Markers in Renal CancerRenal Cell CarcinomaNCT01002937Royal Marsden NHS Foundation Trust182
招募中
不适用
Biomarkers of Renal CancerTumor, SolidAngiomyolipomaRenal Cell CarcinomaOncocytomaNCT05785052Biorek S.R.L.1,000
Unknown
不适用
Biomarkers in Predicting Response to Tamoxifen and Letrozole in Postmenopausal Women With Primary Breast Cancer Treated on Clinical Trial CAN-NCIC-MA17Breast CancerNCT00897065Massachusetts General Hospital957
撤回
不适用
Molecular Markers and Genetic Markers in Patients Undergoing Radiation Therapy for CancerHematopoietic/Lymphoid CancerUnspecified Adult Solid Tumor, Protocol SpecificUnspecified Childhood Solid Tumor, Protocol SpecificNCT00899808Rutgers, The State University of New Jersey