Features of the Clinical Course and Prognosis in Patients With Idiopathic Pulmonary
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- Mortality in 3 years after diagnosed IPAH
研究概览
简要总结
This study will be performed based on a retrospective analysis of the cases of 150-170 patients with IPAH observed at the Research Institute of Clinical Cardiology over the past 10 years, for a comparative assessment of the survival of groups of patients with IPAH diagnosed in the period 2004-2013 and 2014-2023.
The demographic, clinical, functional, hemodynamic characteristics of patients, comorbidity, blood biomarker levels, received PAH-specific and symptomatic therapy will be assessed in order to determine the clinical characteristics of patients with IPAH.
The prospective part of study will include 50 patients with IPAH.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age over 18 years;
- •verified diagnosis of IPAH
排除标准
- •age under 18 years;
- •Other etiology op PAH,
- •ischemic heart disease confirmed by MSCT of the coronary arteries or coronary angiography;
- •diseases of the musculoskeletal system that prevent 6MWT
- •severe liver dysfunction (more than 9 points on the Child-Pugh scale, class C)
- •severe renal dysfunction (CC less than 15 ml/min), need for hemodialysis
结局指标
主要结局
Mortality in 3 years after diagnosed IPAH
时间窗: 3 years
次要结局
未报告次要终点
研究者
Tamila V. Martynyuk, MD, PhD
Professor, Head of pulmonary hypertension department
Russian Cardiology Research and Production Center