Oxytocin Effect on Attentional Bias Towards Emotional Expression Faces in Individuals With High and Low Autistic Traits: A Functional Magnetic Resonance Imaging (fMRI) Study
Overview
- Phase
- Early Phase 1
- Intervention
- screen high autistic subjects
- Conditions
- Healthy
- Sponsor
- University of Electronic Science and Technology of China
- Enrollment
- 120
- Locations
- 1
- Primary Endpoint
- attentional bias toward emotional expression faces
- Last Updated
- 7 years ago
Overview
Brief Summary
to investigate whether oxytocin alter attentional bias towards emotional expression faces in individuals with high and low autistic traits, and the brain mechanism of this effect
Detailed Description
In the present study, investigator plan to use a double-blind, between-subject placebo controlled design.Firstly, all healthy male subjects' autistic trait levels will be assessed by the Autism Spectrum Quotient (ASQ) and only subjects with higher or lower ASQ score will be recruited in the next experiment and divided into high and low subgroup. Then, subjects are randomly assigned to receive either intranasal administration of oxytocin (24 IU) or placebo. 45 min later, subject need to complete an attentional bias task named rapid serial visual presentation (RSVP) task in fMRI scanner.
Investigators
Keith Kendrick
Professor
University of Electronic Science and Technology of China
Eligibility Criteria
Inclusion Criteria
- •healthy subjects without past or current psychiatric or neurological disorders
Exclusion Criteria
- •history of head injury;
- •claustrophobia;
- •medical or psychiatric illness.
Arms & Interventions
high autistic and oxytocin group
subject with high ASQ scores will receive oxytocin treatment
Intervention: screen high autistic subjects
high autistic and oxytocin group
subject with high ASQ scores will receive oxytocin treatment
Intervention: oxytocin
low autistic and oxytocin group
subject with low ASQ scores will receive oxytocin treatment
Intervention: screen low autistic subjects
low autistic and oxytocin group
subject with low ASQ scores will receive oxytocin treatment
Intervention: oxytocin
high autistic and placebo group
subject with high ASQ scores will receive placebo treatment
Intervention: screen high autistic subjects
high autistic and placebo group
subject with high ASQ scores will receive placebo treatment
Intervention: placebo
low autistic and placebo group
subject with low ASQ scores will receive placebo treatment
Intervention: screen low autistic subjects
low autistic and placebo group
subject with low ASQ scores will receive placebo treatment
Intervention: placebo
Outcomes
Primary Outcomes
attentional bias toward emotional expression faces
Time Frame: 1 hour
attentional bias was measured by the accuracy of each emotional faces in the RSVP task
Secondary Outcomes
- brain activity during RSVP task(1 hour)