Ambulance CPAP: use, treatment effect and economics feasibility study

Not Applicable

Completed

• Conditions: Acute respiratory failure (ARF); Respiratory; Acute respiratory failure

• Registration Number: ISRCTN12048261
• Lead Sponsor: niversity of Sheffield

Brief Summary

2018 Protocol article in https://www.ncbi.nlm.nih.gov/pubmed/29946477 protocol 2020 Results article in https://pubmed.ncbi.nlm.nih.gov/32709643/ results (added 28/07/2020) 2021 Results article in https://pubmed.ncbi.nlm.nih.gov/33538686/ results (added 05/02/2021) 2020 Results article in https://pubmed.ncbi.nlm.nih.gov/33456393/ Nested diagnostic accuracy and agreement study (added 18/09/2023)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-08-12
• Study Completion: 2019-02-28
• Last Update Posted: 3 October 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 77

Inclusion Criteria

1. Adults aged over 18
2. Acute respiratory failure defined as respiratory distress with peripheral oxygen saturation below BTS target levels (88% for patients with COPD, 94% for other conditions), despite supplemental oxygen

Exclusion Criteria

1. The time difference between being able to start prehospital CPAP and being able to start in-hospital CPAP is expected to be less than 15 minutes
2. Age < 18 years
3. Known to have terminal illness
4. Known pre-existing lack of capacity (confirmed by relatives, carers or documentary evidence, such as Lasting Power of Attorney)
5. Documented not for resuscitation status
6. Acutely incapacitated patients with valid advanced directive declining non-invasive ventilation or participation in research
7. The patient has an oxygen alert card
8. Anticipated inability to apply CPAP (e.g. facial deformity)
9. Respiratory failure due to chest trauma
10. Contraindication to CPAP (suspected pneumothorax, respiratory arrest, epistaxis, vomiting, hypotension)

Study & Design

• Study Type: Interventional
• Study Design: Not specified