Improvement in Acoustic Voice Characteristics in Functional Dysphonia After Therapy

Completed

• Conditions: Functional Voice Disorder

• Registration Number: NCT02518425
• Lead Sponsor: University of Zurich

Brief Summary

In a retrospective analysis of already existing clinical assessment data from patients with functional voice disorders the following aspects will be sampled, encoded and analysed: Outcomes pre and post treatment of

1. subjective voice symptoms measured by Voice Handicap Index (VHI-9i),

2. perceptual voice symptoms according to Grading-Roughness-Breathiness-Asthenia-Strain Scale (GRBAS Scale),

3. instrumental acoustic analysis parameters Jitter (%), speaking voice profile: mean and range of speaking pitch and intensity, max. intensity and mean pitch of calling voice, singing voice: min./max. and range of pitch and intensity, maximum phonation time, Dysphonia Severity Index (DSI).

Detailed Description

Not available

Study Timeline

• Study Start: 2015-04
• Study First Submitted: 2015-04-09
• Study First Submitted QC: 2015-08-04
• Study First Posted: 2015-08-07
• Primary Completion: 2015-12
• Study Completion: 2015-12
• Status Verified: 2016-05
• Last Update Submitted: 2016-05-13
• Last Update Posted: 2016-05-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• informed consent; patients 20 to 70 years with functional voice disorder; -diagnostics and voice therapy at University Hospital Zurich;
• full pre- and post treatment voice assessment (videostroboscopy, subjective self- assessment, instrumental acoustic and perceptual analysis).

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Exclusion Criteria

• known neurologic and psychiatric disease,
• hearing disorder,
• surgery of the head and neck area or intubation (for any reason) in last 18 months.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Instrumental acoustic voice parameters	Before (initial diagnosis) and after voice therapy, expected average of 11-20 weeks after initial diagnosis)	Instrumental acoustic parameters are determined by a computer-assisted analysis of voice recordings. In the present study the following parameters are measured before and after voice therapy: Jitter % (deviation of fundamental frequency), mean and range of speaking pitch and intensity, maximum intensity and mean pitch of calling voice, minimum and max. and range of pitch and intensity of the singing voice, and the composite measure Dysphonia Severity Index (DSI).

Secondary Outcome Measures

Name	Time	Method
Perceptual voice symptoms	Before (initial diagnosis) and after voice therapy, expected average of 11-20 weeks after initial diagnosis)	Perceptual (hearable) voice symptoms are determined by the examiner before and after voice therapy using GRBAS Scale (Grading-Roughness-Breathiness-Asthenia-Strain Scale).
Subjective voice symptoms	Before (initial diagnosis) and after voice therapy, expected average of 11-20 weeks after initial diagnosis)	Subjective voice symptoms are measured before and after voice therapy by the patient questionnaire "Voice Handicap Index" (VHI-9i).

Trial Locations

Locations (1)

Clinic for Otorhinolaryngology University Hospital Zurich; 🇨🇭 Zurich, ZH, Switzerland