To compare the efficacy of laser alone versus laser with topical application of insulin in the treatment of acne scars over the face

Not yet recruiting

• Conditions: Acne, unspecified,

• Registration Number: CTRI/2025/06/088591
• Lead Sponsor: Dr Sanjay Mailare B

Brief Summary

Acne is chronic inflammatory disorder of pilosebaceous units caused byvarious pathological mechanisms. The clinical features can vary from noninflammatory comedones, inflammatory papules, pustules and nodules at varyingdegrees of depth. Post inflammatory lesions will vary from post inflammatoryhyperpigmentation, atrophic and hypertrophic/keloidal scars. Atrophic scars areicepick ,rolling and boxcar type scars. Many modalities  of treatment are  available to treat atrophic acne scars.Chemical peeling , Fractional CO2 laser, PRP, Microneedling, MNRF (Microneedling Radiofrequency) are some of the treatment options available.

In my study I am goingto compare the efficacy of Fractional CO2 laser versus Fractional CO2 laserwith topical insulin.

Detailed Description

Not available

Study Timeline

• Study Start: 2025-06-21
• Last Update Posted: 2025-10-06

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

1.Patients of either sex above 18 years & below 45 years with atrophic acne scars 2.Patients willing to give a written informed consent.

Exclusion Criteria

• Before starting the study 1.Pregnant and lactating women.
• 2.Patients on anticoagulants/ immunosuppressive therapy 3.Patients with HIV, Bleeding and coagulation disorders, Diabetes mellitus and keloidal tendencies.
• 4.Patients with active local infection 5.Patients with active inflammatory acne 6.Patients on isotretinoin /taken within 6 months During Study 1.If patient wants alternate treatment during the study.
• 2.If patient wants to discontinue the treatment.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Improvement in ECCA global score	12 weeks after treatment

Secondary Outcome Measures

Name	Time	Method
Patient satisfaction score	12 weeks after treatment

Trial Locations

Locations (1)

Chengalpattu Medical College and Hospital; 🇮🇳 Kancheepuram, TAMIL NADU, India

Chengalpattu Medical College and Hospital

🇮🇳Kancheepuram, TAMIL NADU, India

Dr Sanjay Mailare B

Principal investigator

9535706538

sanjaymailare@gmail.com