Comparing the Effect of Hyperoxic and Conventional Fraction of Inspired Oxygen on Oxidative Stress During Abdominal Surgery.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- oxidant and antioxidant response
研究概览
简要总结
Our aim is to compare the effects of 80% and 40% Fraction of inspired oxygen on oxidative stress, antioxidant response (in plasma and bronchoalveolar lavage), extubation quality, preanesthetic and postanesthetic expiration tidal volumes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients undergoing abdominal surgery, between 20-60 years old, with American Society of Anesthesiology score I or II
排除标准
- •Patients with Chronic Obstructive Pulmonary Disease, Diabetes Mellitus, muscle-bone diseases, inflammatory bowel diseases and patients with malnutrition.
- •Patients will be recruited through general surgery service of our hospital
研究组 & 干预措施
40% oxygen
Patients in this group will be ventilated with fraction of inspired oxygen 40% during the surgery.
干预措施: Fraction of inspired oxygen 40% (Other)
80% oxygen
Patients in this group will be ventilated with a fraction of inspired oxygen 80% during the surgery.
干预措施: Fraction of inspired oxygen 80% (Other)
结局指标
主要结局
oxidant and antioxidant response
时间窗: 4 hours
As primary outcome, the effects of different inspired oxygen fractions on oxidative stress and anti-oxidant response in plasma and bronchoalveolar lavage after intubation and prior to extubation will be evaluated
次要结局
- Hemodynamics(4 hours)
研究者
Guniz M.Koksal
Assoc.Prof.
Istanbul University