Prognostic Value Of Short-Term Follow-up Biomarkers After Discharge In hOspitalized Patients With Acute Heart Failure
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 1,500
- 试验地点
- 1
- 主要终点
- The incidence rate (%) of composite endpoint including cardiovascular mortality or hospital readmission
研究概览
简要总结
Several surrogate biomarkers including natriuretic peptide(NP), and growth differentiation factor-15(GDF-15) and ST2 has prognostic significance in heart failure(HF), and reductions in its value may predict clinical improvement. However, there are limited data regarding the prognostic value of these biomarkers during short-term follow-up after discharge in acute decompensated heart failure. The purpose of this study is to evaluate the prognostic value of short-term follow-up surrogate biomarkers for predicting prognosis of hospitalized patients with acute decompensated heart failure.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •the diagnosis of Heart failure requires the following
- •heart failure with reduced ejection fraction ( A 'reduced' ejection fraction (EF) defined as EF <40%): the presence of symptoms and/or signs of HF
- •heart failure with preserved ejection fraction ( A 'preserved' EF defined as EF≥ 40%) requires the all of the followings: a) the presence of symptoms and/or signs of HF b) elevated levels of natriuretic peptides (defined as B-type natriuretic peptide (BNP) >100pg/ml and/or N terminal B-type natriuretic peptide (NT-proBNP) >300pg/ml) c) any structural heart disease (left atrial volume index ≥ 34 mL/m2, left atrial dimension ≥ 50 mm, posterior or septal wall thickness ≥ 11mm)
排除标准
- •any severe condition limiting life less than 3 months
- •the patient is not ready to contact by telephone at the end of the study
结局指标
主要结局
The incidence rate (%) of composite endpoint including cardiovascular mortality or hospital readmission
时间窗: 12 months
Cardiovascular mortality: death due to heart failure aggravation, arrhythmia, cerebrovascular events, myocardial infarction. Hospital readmission: any readmission
次要结局
- The incidence rate (%) of acute coronary syndrome(12 months)
- The incidence rate (%) of cerebrovascular events(12 months)
- The incidence rate (%) of hospital readmission due to heart failure aggravation(12 months)
- The incidence rate (%) of all cause mortality(12 months)
- The incidence rate (%) of hospital readmission(12 months)
- The incidence rate (%) of cardiovascular mortality(12 months)
研究者
Byung-Su Yoo
Professor
Wonju Severance Christian Hospital