Insulin Cardioplegia for Poor Left Ventricular Function
Not Applicable
- Conditions
- Left Ventricular Dysfunction
- Registration Number
- NCT00188994
- Lead Sponsor
- University Health Network, Toronto
- Brief Summary
The purpose of this investigation is to develop a means to improve the recovery of cardiac metabolism and ventricular function following coronary artery bypass surgery (CABG) in patients with poor preoperative ventricular function (e.g. ejection fraction \<40%).
- Detailed Description
Hypothesis
Insulin added to blood cardioplegia will improve the results of Coronary Artery Bypass Graft by reducing the incidence of low output syndrome (i.e., the requirement for inotropic or balloon pump assistance) in patients with a preoperative ejection fraction \<40%.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 800
Inclusion Criteria
- Patient has been referred for isolated coronary bypass surgery.
- LV grade 3 or 4, LVEF <40% by angio, echo, RNA.
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Exclusion Criteria
- Patient is undergoing reoperative surgery (i.e., has had any previous cardiac surgery)
- Surgeon has planned another procedure in addition to coronary bypass surgery (e.g., valve repair, replacement, ascending aorta repair or replacement, left ventricular aneurysm resection, repair of congenital defect, carotid surgery, repair of abdominal aortic aneurysm).
- Patient is scheduled for minimally invasive surgery.
- More recent assessment of LV function with LV grade 1 0r 2, LVEF>40%.
- 5 or 6 days post MI.
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Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Low Output Syndrome
- Secondary Outcome Measures
Name Time Method Total Troponin I Release
Trial Locations
- Locations (1)
University Health Network
🇨🇦Toronto, Ontario, Canada