Effects of Standing on Glycemia in Prediabetic Adults

Not Applicable

Completed

• Conditions: Prediabetes
• Interventions: Other: Sitting CGM; Other: Sitting OGTT; Other: Standing CGM; Other: Standing OGTT

• Registration Number: NCT01884792
• Lead Sponsor: University of Minnesota

Brief Summary

The study is a crossover, pilot trial examining the acute effects of standing on blood sugar in prediabetic, working adults. Participants will complete oral glucose tolerance testing, once while sitting and once while standing. They will also wear a continuous blood sugar monitor once while sitting at their desk for a week and once while using their desk as a sit-stand desk with a goal of standing intermittently for at least half of the work day. Physical activity levels will be measured with an accelerometer. The primary study hypothesis is that blood sugar will differ between the sitting and standing conditions for each of the tests performed.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2013-03
• Study First Submitted: 2013-06-19
• Study First Submitted QC: 2013-06-21
• Study First Posted: 2013-06-24
• Primary Completion: 2013-07
• Study Completion: 2013-09
• Status Verified: 2014-09
• Last Update Submitted: 2014-09-12
• Last Update Posted: 2014-09-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Fasting blood glucose >100 mg/dl
• Employed full-time working at least 35 hours/week
• Able to safely begin a light physical activity program

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Exclusion Criteria

• Heart disease
• Renal disease
• Peripheral neuropathy
• Retinopathy
• PAD
• Lower limb amputation
• pregnancy
• active substance abuse
• current smoker
• psychiatric disorder
• severe visual impairment
• immune-compromised individuals,
• enrollment in a physical activity study
• use of insulin or an insulin pump

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Standing Continuous Glucose Monitor	Sitting CGM	Participants are instructed to stand intermittently for at least half of their work day during this 5 day period. Blood sugar is monitored and physical activity is tracked with an accelerometer.
Sitting Oral Glucose Tolerance Test	Sitting OGTT	An OGTT is performed while the subject sits at their desk for the entire 2-hour period. 5 blood sugar measurements are taken and a 75g dextrose beverage is consumed following the first, baseline blood sugar reading. The blood sugar is then measured every 30 minutes up to 120 min.
Sitting Continuous Glucose Monitor	Standing CGM	A continuous blood glucose monitor is worn for 5 days while at work. In the sitting condition the participant only sits at their desk for the duration of the week. Blood sugar is monitored 4 times per day to calibrate the CGM and an accelerometer is worn to track physical activity.
Sitting Oral Glucose Tolerance Test	Standing OGTT	An OGTT is performed while the subject sits at their desk for the entire 2-hour period. 5 blood sugar measurements are taken and a 75g dextrose beverage is consumed following the first, baseline blood sugar reading. The blood sugar is then measured every 30 minutes up to 120 min.
Standing Oral Glucose Tolerance Test	Sitting OGTT	The participant stands at their desk for the duration of the 2-hour blood sugar test. The same procedure is performed as in the sitting condition.
Standing Oral Glucose Tolerance Test	Standing OGTT	The participant stands at their desk for the duration of the 2-hour blood sugar test. The same procedure is performed as in the sitting condition.
Sitting Continuous Glucose Monitor	Sitting CGM	A continuous blood glucose monitor is worn for 5 days while at work. In the sitting condition the participant only sits at their desk for the duration of the week. Blood sugar is monitored 4 times per day to calibrate the CGM and an accelerometer is worn to track physical activity.
Standing Continuous Glucose Monitor	Standing CGM	Participants are instructed to stand intermittently for at least half of their work day during this 5 day period. Blood sugar is monitored and physical activity is tracked with an accelerometer.

Primary Outcome Measures

Name	Time	Method
Blood sugar area under the curve	2 hours	The area under the curve following the 2 hour blood sugar tests.

Secondary Outcome Measures

Name	Time	Method
Accelerometer counts	4 hours and 2 5 day periods	Accelerometer counts in the 4 testing conditions.

Trial Locations

Locations (1)

Department of Human Services; 🇺🇸 St. Paul, Minnesota, United States